Vancomycin-Associated Nephrotoxicity: Grave Concern or Death by Character Assassination?
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چکیده
منابع مشابه
The Nephrotoxicity of Vancomycin
Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist. Herein, we critically examine available data in adult patients pertinent to this question. We review the pharmacokinetics/pharmacodynamics of vancomycin metabolism. Efficacy and sa...
متن کامل9 Vancomycin - Induced Nephrotoxicity
Nephrotoxicity associated with vancomycin administration has been a topic of debate for over five decades (Tables 1 & 2). Vancomycin is a glycopeptide antibiotic excreted by the kidney and has been used extensively, especially for methicillin-resistant staphylococcus aureus (MRSA) and for many strains of pathogenic staphylococcus epidermis. The nephrotoxic potential of vancomycin is neither ful...
متن کاملPharmacodynamic Characteristics of Nephrotoxicity Associated With Vancomycin Use in Children.
BACKGROUND Limited studies incorporating population-based pharmacokinetic modeling have been conducted to determine pharmacodynamic indices associated with nephrotoxicity during vancomycin exposure in children. METHODS A retrospective cohort analysis was conducted from September 2003 to December 2011 at 2 hospitals. Nephrotoxicity was defined as an increase in serum creatinine concentration (...
متن کاملVancomycin nephrotoxicity: myths and facts.
Vancomycin is a key antibiotic in the management of severe Gram-positive infections. Recent emergence of methicillin-resistant staphylococcal strains with reduced susceptibility to vancomycin has prompted internists to administer high-dose treatment to achieve trough levels of 15 to 20 mg/l. Such high doses might be causative in nephrotoxicity. The risk further increases in patients who are cri...
متن کاملReply to "Vancomycin-induced nephrotoxicity".
S. J. van Hal, D. L. Paterson, T. P. Lodise Department of Microbiology & Infectious Diseases, Royal Prince Alfred Hospital, Sydney, Australia; Antibiotic Resistance & Mobile Elements Group, Microbiology and Infectious Diseases Unit, School of Medicine, University of Western Sydney, Sydney, Australia; University of Queensland Centre for Clinical Research (UQCCR), Herston, Australia; Albany Colle...
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ژورنال
عنوان ژورنال: The American Journal of Medicine
سال: 2010
ISSN: 0002-9343
DOI: 10.1016/j.amjmed.2009.05.031